Increased frequency of HLA-Bw62 and Bw35 CREG antigens in HLA-B27 negative ankylosing spondylitis.

Abstract

67 patients with ankylosing spondylitis (AS) were tissue-typed for HLA-A, -B and -C antigens. HLA-Bw62 was found in 6 of 13 (46%) HLA-B27 negative patients, compared to 9% in HLA-B27 positive AS (p greater than 0.01) and 10% in healthy blood donors (p greater than 0.001). HLA-Bw62, a split of the previous HLA-B15, belongs to the HLA-Bw35 CREG antigens, 11 of 13 (85%) of HLA-B27 negative patients had an HLA-Bw35 CREG antigen. The present results are interpreted as an indication of a direct involvement of the HLA-B locus in the pathogenesis of AS.

• Authors: P Wagener, H Zeidler, G Eckert, H Deicher
• Journal: Zeitschrift fur Rheumatologie (Z Rheumatol) 1984 Sep-Oct Vol. 43 Issue 5 Pg. 253-7 ISSN: 0340-1855 [Print] Germany
• PMID: 6335328 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• HLA-B Antigens
• HLA-B15 Antigen
• HLA-B27 Antigen
• HLA-B35 Antigen
• HLA-Bw62

Topics

• Adult
• Female
• Gene Frequency
• HLA Antigens (genetics)
• HLA-B Antigens
• HLA-B15 Antigen
• HLA-B27 Antigen
• HLA-B35 Antigen
• Humans
• Male
• Middle Aged
• Phenotype
• Spondylitis, Ankylosing (genetics)