Abstract |
The purpose of this study was to evaluate protein-losing enteropathy in cirrhotic patients by assaying the intestinal clearance of alpha 1 antitrypsin (C alpha 1), 28 patients were divided into 5 groups: group A = 4 controls, group B = 6 patients with peptic ulcer, group C = 5 cirrhotic patients without esophageal varices (EV), group D = 6 cirrhotic patients with EV but without ascites, group E = 7 cirrhotic patients with EV and ascites. A significant increase in C alpha 1 was found only in groups D and E. The C 1 level was equal to the mean level found in controls multiplied by 2.5 and added to 2 standard deviations. Increases in C alpha 1 levels were not statistically significant when ascites or gastrointestinal involvement were present. C alpha 1 was significantly correlated to the size of EV (p greater than 0.05) and with the Child ratio (p greater than 0.01). No significant correlation was found between C alpha 1 and serum albumin or prothrombin.
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Authors | J F Bretagne, P Lemee, E Esvant, J Gastard |
Journal | La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris
(Sem Hop)
Vol. 58
Issue 10
Pg. 575-7
(Mar 11 1982)
France |
Vernacular Title | Evaluation de l'entéropathie exsudative chez le patient cirrhotique par la mesure de la clairance intestinal de l'alpha 1-antitrypsine. |
PMID | 6278598
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Humans
- Intestinal Mucosa
(metabolism)
- Liver Cirrhosis, Alcoholic
(complications, metabolism)
- Protein-Losing Enteropathies
(diagnosis, etiology, metabolism)
- alpha 1-Antitrypsin
(metabolism)
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