2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research.

Abstract

Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.

• Authors: M M Slaughter, R F Miller
• Journal: Science (New York, N.Y.) (Science) Vol. 211 Issue 4478 Pg. 182-5 (Jan 09 1981) ISSN: 0036-8075 [Print] United States
• PMID: 6255566 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Aminobutyrates
• Organophosphorus Compounds
• Receptors, Neurotransmitter
• 2-amino-4-phosphonobutyric acid

Topics

• Action Potentials (drug effects)
• Aminobutyrates (pharmacology)
• Animals
• In Vitro Techniques
• Light
• Necturus
• Organophosphorus Compounds (pharmacology)
• Receptors, Neurotransmitter (drug effects)
• Retina (cytology, drug effects, physiology, radiation effects)
• Vision, Ocular (drug effects)