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Effect of methyl substitution on the irritancy of dibenz[b,f]1,4-oxazepine(CR).

Abstract
The irritant properties of 3 methylated derivatives of dibenz[b,f]1,4-oxazepine (CR) have been investigated, using the guinea-pig blepharospasm test and isolated cat eye preparations, and compared with the irritancy of the unsubstituted CR molecule. In both tests, the 11-methyl derivative was non-irritant whereas 3 Me-CR and 9 Me-CR retained some irritancy although both were less potent than CR itself. The possible significance of these results are discussed in relation to earlier biochemical studies.
AuthorsD M Green, D J Balfour, A Muir
JournalToxicology (Toxicology) Vol. 12 Issue 2 Pg. 151-3 (Feb 1979) ISSN: 0300-483X [Print] Ireland
PMID473231 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Dibenzoxazepines
  • Irritants
Topics
  • Animals
  • Blepharospasm (chemically induced)
  • Cats
  • Ciliary Body (innervation)
  • Dibenzoxazepines (pharmacology)
  • Eye (drug effects)
  • Guinea Pigs
  • Irritants (pharmacology)
  • Methylation
  • Structure-Activity Relationship

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