Abstract |
The irritant properties of 3 methylated derivatives of dibenz[b,f]1,4-oxazepine (CR) have been investigated, using the guinea-pig blepharospasm test and isolated cat eye preparations, and compared with the irritancy of the unsubstituted CR molecule. In both tests, the 11-methyl derivative was non- irritant whereas 3 Me-CR and 9 Me-CR retained some irritancy although both were less potent than CR itself. The possible significance of these results are discussed in relation to earlier biochemical studies.
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Authors | D M Green, D J Balfour, A Muir |
Journal | Toxicology
(Toxicology)
Vol. 12
Issue 2
Pg. 151-3
(Feb 1979)
ISSN: 0300-483X [Print] Ireland |
PMID | 473231
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Dibenzoxazepines
- Irritants
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Topics |
- Animals
- Blepharospasm
(chemically induced)
- Cats
- Ciliary Body
(innervation)
- Dibenzoxazepines
(pharmacology)
- Eye
(drug effects)
- Guinea Pigs
- Irritants
(pharmacology)
- Methylation
- Structure-Activity Relationship
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