Abstract |
In contrast to intravenously-administered crystallene glucagon, which acts for 20 minutes only, the depot form, zinc protamine glucagon, shows a prolonged haemodynamic action. Fourteen patients with pre-existing heart failure received a single dose of 20 mg Zn protamine glucagon intramuscularly. The stroke volume and cardiac output were increased, whereas the mean and end-diastolic pulmonary pressure were decreased, indicating a positive inotropic action of the administered drug. Heart rate and mean arterial pressure remained almost unchanged. The haemodynamic changes started 60 minutes after intramuscular administration of the drug, reached a maximum effect at 3 hours and started to decrease after the fourth hour. Zn protamine glucagon can, therefore, be considered a beneficial drug in the treatment of digitalis-resistant heart failure on the basis of its long duration of action and easy route of administration.
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Authors | M Pichler, G Kleinberger, H Lochs, D Magometschnigg, H Pall |
Journal | Wiener klinische Wochenschrift
(Wien Klin Wochenschr)
Vol. 91
Issue 2
Pg. 49-51
(Jan 19 1979)
ISSN: 0043-5325 [Print] Austria |
Vernacular Title | Hämodynamische Wirkungen von Depot-Zink-Protamin-Glukagon bei kardialer Dekompensation. |
PMID | 433280
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Glucagon
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Topics |
- Aged
- Blood Pressure
(drug effects)
- Delayed-Action Preparations
- Female
- Glucagon
(therapeutic use)
- Heart Failure
(drug therapy)
- Heart Rate
(drug effects)
- Humans
- Male
- Middle Aged
- Pulmonary Circulation
(drug effects)
- Stroke Volume
(drug effects)
- Vascular Resistance
(drug effects)
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