[Indications and results of combined urokinase-lys plasminogen in acute ischemic pathology of the legs].

Abstract

Low dose urokinase-lys plasminogen was used to treat 10 patients with acute ischemia of lower limbs. Preliminary results are reported and indications defined, the combination producing effective relief and being very well tolerated biologically and clinically. All patients presented clear signs of ischemia provoking a short term risk for the limb. Direct femoral puncture arteriography of the ischemic limb was an essential pretreatment investigation. A thin catheter left in contact with the thrombus allowed localized fibrinolysis to be performed. Follow up arteriography examinations assessed clinicopathologic results, while biologic surveillance of principal coagulation parameters showed a lack of significant alterations during treatment. Ischemic signs were totally relieved in 7 cases, with arterial repermeabilization allowing recuperation of one (3 cases) or both (2 cases) distal pulses. Persistence of a popliteal thrombus in one case required a fogarty after a direct approach and the limb was saved. Two patients had to be amputated because of delayed treatment. These encouraging results suggest that this procedure of local thrombolysis be reserved for popliteal or infra-popliteal occlusions accompanied by sensory-motor signs and of recent (less than 72 hours) onset. Follow up for 8 months is insufficient but has shown the absence of deterioration, but this is obviously a function of the natural course of the underlying atheromatous disease.

• Authors: C Giraud, F Joffre, J Tasrini, J M Carrie, M D Vandenbroek, P Puel, A Cerene
• Journal: Journal des maladies vasculaires (J Mal Vasc) Vol. 10 Issue 4 Pg. 321-6 ( 1985) ISSN: 0398-0499 [Print] France
• Vernacular Title: Indications et résultats de l'association urokinase-lys plasminogène dans la pathologie ischémique aiguë des membres inférieurs.
• PMID: 4093720 (Publication Type: Journal Article)

Chemical References

• Peptide Fragments
• lysyl-plasminogen
• Plasminogen
• Urokinase-Type Plasminogen Activator

Topics

• Acute Disease
• Adult
• Aged
• Angiography
• Drug Therapy, Combination
• Female
• Humans
• Ischemia (diagnostic imaging, drug therapy)
• Leg (blood supply)
• Male
• Peptide Fragments (therapeutic use)
• Plasminogen (therapeutic use)
• Urokinase-Type Plasminogen Activator (therapeutic use)