Interspecies pharmacokinetic scaling of Sch 34343.

Abstract	Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight. The pertinent pharmacokinetic parameters tested are apparent and steady-state volumes of distribution, total body clearance, elimination phase half-life, and mean residence time. This study showed that the extrapolation of animal data to humans on a new investigational drug, Sch 34343, can be potentially useful.
Authors	M Chung, E Radwanski, D Loebenberg, C C Lin, E Oden, S Symchowicz, R P Gural, G H Miller
Journal	The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 15 Suppl C Pg. 227-33 (Jun 1985) ISSN: 0305-7453 [Print] England
PMID	4030550 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Bacterial Agents Lactams Sch 34343
Topics	Animals Anti-Bacterial Agents (administration & dosage, blood, metabolism) Body Weight Dogs Humans Injections, Intravenous Kinetics Lactams Macaca fascicularis Male Mice Rabbits Rats Saimiri Species Specificity

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