Effect of renal function and dialysis on temocillin pharmacokinetics.

Abstract

Temocillin pharmacokinetics in renal impairment were investigated following an intravenous bolus injection of 15 mg/kg. The 28 patients were divided into 5 groups of varying renal function, from normal to uraemic [including a group being treated with haemodialysis and a group on continuous ambulatory peritoneal dialysis (CAPD)]. The distribution of temocillin into the tissues was not affected by renal dysfunction. Uraemia as compared to normal renal function resulted in a 4.3-fold decrease in temocillin clearance and a 3.1-fold decrease in urinary recovery over 24 hours, as well as a 5- and 3.7-fold increase in the beta half-life and the area under the curve (AUC), respectively. Haemodialysis doubled the serum clearance and halved the beta half-life of temocillin in the uraemic subject, but CAPD over 24 hours eliminated only 8% of the temocillin dose, resulting in a minimal change in pharmacokinetics. Temocillin dosage adjustments in renal failure are proposed.

• Authors: J Boelaert, R Daneels, M Schurgers, G Mellows, A J Swaisland, A M Lambert, H W Van Landuyt
• Journal: Drugs (Drugs) Vol. 29 Suppl 5 Pg. 109-13 ( 1985) ISSN: 0012-6667 [Print] New Zealand
• PMID: 4029012 (Publication Type: Journal Article)

Chemical References

• Penicillins
• temocillin

Topics

• Humans
• Kidney (metabolism)
• Kidney Diseases (metabolism)
• Kidney Failure, Chronic (metabolism)
• Kinetics
• Penicillins (metabolism)
• Peritoneal Dialysis, Continuous Ambulatory
• Renal Dialysis