Plasma vitamin C and uterine cervical dysplasia.

Abstract

Plasma concentrations of vitamin C were determined in a case-control study of women (n = 80) who had sought a Papanicolaou test in the Bronx Municipal Hospital Center. Controls (n = 34) were women having negative cytologic tests, negative colposcopic findings, and no known gynecologic dysfunction. Cases (n = 46) were defined as women who had either one positive or two consecutive suspicious Papanicolaou smears in a 12-month period. The mean concentration of vitamin C in the plasma was significantly lower in the cases than in the controls (0.36 versus 0.75 mg/dl, p less than 0.0001). Cases were further stratified according to the histopathologic diagnosis. The data direct attention to a possible etiologic association of vitamin C in human cervical epithelial abnormalities. A clinical trial with vitamin C intervention is suggested.

• Authors: S L Romney, C Duttagupta, J Basu, P R Palan, S Karp, N S Slagle, A Dwyer, S Wassertheil-Smoller, J Wylie-Rosett
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 151 Issue 7 Pg. 976-80 (Apr 01 1985) ISSN: 0002-9378 [Print] United States
• PMID: 3985059 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ascorbic Acid

Topics

• Adult
• Ascorbic Acid (blood)
• Diet (adverse effects)
• Female
• Humans
• Middle Aged
• Papanicolaou Test
• Uterine Cervical Dysplasia (blood, etiology, pathology)
• Vaginal Smears