[Double blind randomized trial of metopimazine: for postoperative nausea and vomiting after cholecystectomy].

Abstract

Eighty-four patients submitted to cholecystectomy were randomly assigned in a double-blind study either to an intravenous dose of 10 mg of metopimazine, three times D-1, for two days or to an identically administered placebo. A definite superiority of metopimazine as an anti-emetic drug was demonstrated. General acceptance was excellent, but arterial pressure might be looked over closely when metopimazine was administered intravenously immediately after a general anesthesia.

• Authors: C Rodary, A Elman, M Durand, J Cohen-Solal, J N Maillard
• Journal: Annales de l'anesthesiologie francaise (Ann Anesthesiol Fr) Vol. 20 Issue 2 Pg. 118-20 ( 1979) ISSN: 0003-4061 [Print] France
• Vernacular Title: Essai comparatif en double insu de la métopimazine: sur le syndrome émétique post-opératoire après cholécystectomie.
• PMID: 38705 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Isonipecotic Acids
• Phenothiazines

Topics

• Adult
• Aged
• Cholecystectomy
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Isonipecotic Acids (therapeutic use)
• Male
• Middle Aged
• Phenothiazines (therapeutic use)
• Postoperative Complications (drug therapy)
• Vomiting (drug therapy)