Crystal structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone.

Abstract

The structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone, C13H13ClFNO4, at 100 K has monoclinic (P21) symmetry. The compound has a polymeric structure propagated by a screw axis parallel to the b axis with N-H⋯O hydrogen bonding. It is of inter-est with respect to efforts in the synthesis of a candidate anti-cancer drug, parsaclisib.

• Authors: Victor Li, Glenn P A Yap, Chaoying Ni
• Journal: Acta crystallographica. Section E, Crystallographic communications (Acta Crystallogr E Crystallogr Commun) Vol. 80 Issue Pt 4 Pg. 375-377 (Mar 01 2024) ISSN: 2056-9890 [Print] England
• PMID: 38584728 (Publication Type: Journal Article)
• Copyright: © Li et al. 2024.