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Improvement of cardiac conduction after hyperventilation in tricyclic antidepressant overdose.

Abstract
Three patients wtih severe cardiotoxicity secondary to tricyclic antidepressant (TCA) overdosage were treated with induced mechanical hyperventilation. All three demonstrated marked QRS narrowing, reflecting improved intracardiac conduction, after hyperventilation therapy. Such therapy may help to prevent or abolish ventricular dysrhythmias, often a feature of life-threatening TCA overdoses.
AuthorsH A Bessen, J T Niemann
JournalJournal of toxicology. Clinical toxicology (J Toxicol Clin Toxicol) 1985-1986 Vol. 23 Issue 7-8 Pg. 537-46 ISSN: 0731-3810 [Print] United States
PMID3831377 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Amitriptyline
  • Dopamine
Topics
  • Adult
  • Amitriptyline (blood, poisoning)
  • Blood Pressure
  • Coma
  • Dopamine (therapeutic use)
  • Female
  • Heart Conduction System (drug effects)
  • Humans
  • Hyperventilation
  • Male
  • Respiration, Artificial
  • Suicide, Attempted

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