Mutagenicity of some substituted 1-phenyl-3,3-dimethyltriazenes. II. Chromosomal aberrations in human peripheral lymphocytes in vitro.

Abstract

The chromosome-breaking activity of four 1-(phenyl)-3,3-dimethyltriazenes was tested in vitro on human peripheral blood lymphocytes using S9 mix as a metabolic activation system. 1-(4-Nitrophenyl)-3,3-dimethyltriazene was the most active compound. The difference in the frequency of chromosomal aberrations in a test with and without metabolic activation was significant at the 1% level of significance. The lowest frequency of chromosomal aberrations was induced by 1-(4-methylphenyl)-3,3-dimethyltriazene which, under the conditions of this experiment, is the least stable and probably rapidly degraded to non-active compounds. The chromosomal aberrations were also induced by 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(4-bromophenyl)-3,3-dimethyltriazene, this activity was unrelated to metabolic activation.

• Authors: P Rössner, M Cerná, P Lepsi, H Pohlová
• Journal: Mutation research (Mutat Res) Vol. 190 Issue 3 Pg. 183-6 (Mar 1987) ISSN: 0027-5107 [Print] Netherlands
• PMID: 3821778 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Mutagens
• Triazenes
• 1-(4-chlorophenyl)-3,3-dimethyltriazene
• 1-(4-nitrophenyl)-3,3-dimethyltriazene
• 1-(4-bromophenyl)-3,3-dimethyltriazene
• 1-phenyl-3,3-dimethyltriazene

Topics

• Cells, Cultured
• Chromosome Aberrations
• Humans
• Lymphocytes (cytology, drug effects)
• Mutagenicity Tests
• Mutagens (toxicity)
• Structure-Activity Relationship
• Triazenes (toxicity)