Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition.

Abstract

OBJECTIVE:

We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition.

METHODS:

MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F]flutemetamol, and bioelectrical impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network.

RESULTS:

There was a significant interaction of APOE ε4 carrier status with body fat mass index, visceral fat area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements in the APOE ε4 carrier with lower DMN-CEN FC.

CONCLUSION:

The present results highlight the detrimental effect of APOE ε4 carrier status on the associations between the fat-related body composition measurements and FC in the MCI patients with Aβ accumulation.

• Authors: In Hyeok Choi, Sheng-Min Wang, Yoo Hyun Um, Hyun Kook Lim, Chang Uk Lee, Dong Woo Kang
• Journal: Psychiatry investigation (Psychiatry Investig) Vol. 20 Issue 12 Pg. 1177-1184 (Dec 2023) ISSN: 1738-3684 [Print] Korea (South)
• PMID: 38163657 (Publication Type: Journal Article)