Multicystic Clear Cell Renal Tumors With Low-grade Nuclear Features: Time to Include TFE3 Translocation-associated Carcinomas.

Abstract

TFE3-rearranged renal cell carcinoma (RCC) is a distinct, uncommon entity with more than 20 different fusion partners identified; however, histomorphology may be suggestive of specific fusion partners in select TFE3-rearranged RCCs. For example, most MED15::TFE3 fusion associated RCCs exhibit multilocular cystic morphology, mimicking multilocular cystic renal neoplasm of low malignant potential. Here we present a case of MED15::TFE3 RCC in an older adult and review the literature with an emphasis on practical diagnostic approaches for predominantly cystic, low-grade, clear cell renal tumors.

• Authors: Qi Cai, Jeffrey Gagan, Prasad Koduru, Jeffrey Cadeddu, Rajal B Shah, Payal Kapur, Doreen N Palsgrove
• Journal: Advances in anatomic pathology (Adv Anat Pathol) (Nov 06 2023) ISSN: 1533-4031 [Electronic] United States
• PMID: 37937590 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.