The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients.

Abstract

OBJECTIVES:

The present study aimed to investigate the impact of BRCA1 protein expression on the patients' outcome of ovarian serous carcinoma, and its correlation with different clinicopathologic features.

METHODS:

Immunohistochemistry with BRCA1 was done for 80 cases of ovarian serous carcinoma that had a positive family history. Correlation with clinico-pathologic variables and patients' outcomes was investigated.

RESULTS:

BRCA1 expression was detected in 61.2% of the studied cases. A significant relation with patients' age, tumor grade and tumor stage was found (P<0.05). Also, there was a significant decrease in disease free survival (DFS) & overall survival (OS) in the positive BRCA1 group. Metastasis, recurrence, residual disease, and mortality rate showed significantly higher figures in patient with BRCA1 expression (P<0.05).

CONCLUSION:

Positive BRCA1 expression had proven to be associated with advanced stage & grade of tumors, as well as worsened prognostic survival parameters (metastasis, recurrence, residual disease, and mortality) in patients with ovarian serous carcinoma.

• Authors: Nancy H Amin, Bassant A Ahmed, Amany A Abou-Bakr, Saad Sayed Eissa, Hanan R Nassar, Mai Gad, Mohab Eissa
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 24 Issue 10 Pg. 3613-3620 (Oct 01 2023) ISSN: 2476-762X [Electronic] Thailand
• PMID: 37898870 (Publication Type: Journal Article)

Chemical References

• BRCA1 Protein
• BRCA1 protein, human

Topics

• Female
• Humans
• BRCA1 Protein (genetics)
• Ovarian Neoplasms (pathology)
• Egypt (epidemiology)
• Carcinoma, Ovarian Epithelial
• Cystadenocarcinoma, Serous (pathology)