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Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS.

Abstract
Cryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.
AuthorsRachael Dangarembizi, Rebecca Drummond
JournalTrends in neurosciences (Trends Neurosci) Vol. 46 Issue 12 Pg. 1003-1004 (Dec 2023) ISSN: 1878-108X [Electronic] England
PMID37806831 (Publication Type: Journal Article)
CopyrightCopyright © 2023 Elsevier Ltd. All rights reserved.
Chemical References
  • Antifungal Agents
Topics
  • Animals
  • Mice
  • AIDS-Related Opportunistic Infections (complications, drug therapy)
  • Meningitis, Cryptococcal (complications, drug therapy)
  • Antifungal Agents (therapeutic use)
  • HIV Infections (complications, drug therapy)
  • Mesencephalon

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