Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16).

Abstract

Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide. Both achieved a partial remission after only one cycle. One patient had a "nonfunctioning" tumor that had previously regressed on mitotane whereas the second patient presented with classical Cushing's syndrome. Although the latter patient's urinary 17-ketosteroids normalized while receiving mitotane, the tumor itself failed to regress objectively. Cisplatin plus etoposide appears to be an active combination for the treatment of metastatic adrenal cortical carcinoma.

• Authors: D H Johnson, F A Greco
• Journal: Cancer (Cancer) Vol. 58 Issue 10 Pg. 2198-202 (Nov 15 1986) ISSN: 0008-543X [Print] United States
• PMID: 3756767 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Etoposide
• Mitotane
• Cisplatin

Topics

• Adrenal Cortex Neoplasms (drug therapy)
• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Carcinoma (drug therapy)
• Cisplatin (administration & dosage)
• Etoposide (administration & dosage)
• Female
• Humans
• Male
• Mitotane (administration & dosage)
• Neoplasm Metastasis