Abstract | PURPOSE:
Antithrombin (AT) deficiency is a well-known inherited risk factor for venous thromboembolism (VTE). However, F V Leiden and F II20210a mutations have drawn much more attention in the recent years. Therefore, we have decided to analyze the frequency of antithrombin deficiency in different cohorts of patients and tried to formulate indications for its testing. RESULTS: RECOMMENDATION: We consider antithrombin testing useful in patients with thrombosis occuring up to 45 years of age without any risk factors. Namely, females with VTE in pregnancy and puerperium should be tested as well as females with thrombosis on COC, if VTE occurred within the first year of their use. CONCLUSION: In spite of degressive interest in thrombophilia work up, we still consider antithrombin testing useful in defined clinical situations.
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Authors | Maria Anna Pejková, Eva Ivanová, Petr Sadílek, Radovan Malý, Zuzana Thibaud, Petr Dulíček |
Journal | Acta medica (Hradec Kralove)
(Acta Medica (Hradec Kralove))
Vol. 66
Issue 1
Pg. 19-23
( 2023)
ISSN: 1805-9694 [Electronic] Czech Republic |
PMID | 37384805
(Publication Type: Journal Article)
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Chemical References |
- Antithrombins
- Anticoagulants
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Topics |
- Female
- Pregnancy
- Humans
- Venous Thromboembolism
(epidemiology, genetics)
- Thrombophilia
(genetics)
- Thrombosis
- Antithrombins
- Anticoagulants
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