Therapeutic Efficacy of AFree Oral Spray on the Symptoms and Course of Moderate and Severe COVID-19 in the Field Hospital.

Abstract

BACKGROUND/AIM:

A prospective randomized, open-label, single-blinded clinical trial was conducted to evaluate the efficacy of AFree on the symptoms and course of moderate and severe COVID-19 in the field hospital.

PATIENTS AND METHODS:

Two hundred hospitalized patients diagnosed with COVID-19 were enrolled. The patients were randomized into 100 patients in the interventional AFree group and 100 in the control group. The AFree group patients were treated with AFree oral spray in conjunction with the standard COVID-19 treatment protocol, while the control group of patients were treated with only standard care.

RESULTS:

Patients of the AFree group demonstrated a remarkedly faster improvement in all COVID-19-related symptoms, resulting in a shorter time for complete recovery than the control group. More importantly, they showed a shorter time for complete viral clearance. Adding AFree to the standard of care protocol also significantly improved the restoration of taste and smell and reduced lung infiltration. Additionally, the patients in the AFree group also exhibited fewer adverse effects related to treatment.

CONCLUSION:

AFree oral spray is a simple-to-use, safe, and effective adjunctive treatment for moderate and severe COVID-19 cases. AFree oral spray was demonstrated to potentially be effective for COVID-19 prevention.

• Authors: Duong T Tran, Truong N Pham, Nhung H T Nguyen, Hau D Tran, Huy Q Hoang, Anh K Nguyen, B O Han, Ba X Hoang
• Journal: In vivo (Athens, Greece) (In Vivo) 2023 Jul-Aug Vol. 37 Issue 4 Pg. 1743-1750 ISSN: 1791-7549 [Electronic] Greece
• PMID: 37369463 (Publication Type: Randomized Controlled Trial, Journal Article)
• Copyright: Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Oral Sprays

Topics

• Humans
• COVID-19
• Oral Sprays
• SARS-CoV-2
• COVID-19 Drug Treatment
• Prospective Studies
• Mobile Health Units
• Treatment Outcome