Abstract | OBJECTIVE: METHODS: A retrospective study was conducted in patients who visited the Department of Child Neurology, National Hospital Organization Nishiniigata Chuo Hospital and the Department of Pediatrics, National Hospital Organization Nagasaki Medical Center. Among patients who had been diagnosed with juvenile myoclonic epilepsy, those who received lacosamide as adjunctive therapy for refractory generalized tonic-clonic seizures for at least 2 years from January 2017 to December 2022, and who achieved seizure freedom or >50% seizure reduction in tonic-clonic seizures were included. The medical records and neurophysiological data of the patients were reviewed retrospectively. RESULTS: Four patients met the inclusion criteria. The mean age at the onset of epilepsy was 11.3 years (range 10-12), and the mean age of starting lacosamide was 17.5 years (range 16-21). All patients received two or more antiseizure medications prior to lacosamide. Three of four patients had seizure freedom for more than 2 years, and the one remaining patient had >50% seizure reduction for more than one year. Only one patient had recurrent myoclonic seizures after starting lacosamide. The mean lacosamide dose at the last visit was 425 mg/day (range 300-600). CONCLUSION:
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Authors | Yu Kobayashi, Ryoko Honda, Kei Yamada, Moemi Hojo, Masaki Miura, Eijun Seki, Tomonori Ono, Jun Tohyama |
Journal | Brain & development
(Brain Dev)
Vol. 45
Issue 8
Pg. 451-455
(Sep 2023)
ISSN: 1872-7131 [Electronic] Netherlands |
PMID | 37308336
(Publication Type: Case Reports)
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Copyright | Copyright © 2023 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Lacosamide
- Anticonvulsants
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Topics |
- Humans
- Child
- Adolescent
- Young Adult
- Adult
- Lacosamide
(therapeutic use)
- Myoclonic Epilepsy, Juvenile
(complications, drug therapy)
- Retrospective Studies
- Anticonvulsants
- Seizures
(drug therapy, chemically induced)
- Epilepsy, Generalized
- Epilepsy, Tonic-Clonic
(drug therapy)
- Treatment Outcome
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