Comparing the efficacy of three methods of permethrin application in pediculosis capitis: A randomized clinical trial.

Abstract

BACKGROUND:

Pediculosis capitis, also known as head lice, is a common problem that affects individuals of different socio-economic backgrounds. Permethrin is generally considered the first-line treatment option for head lice.

AIMS:

The objective of this study was to evaluate and compare the therapeutic effects of three different methods of permethrin treatment for head lice.

METHOD:

A parallel, randomized clinical trial was conducted on 157 patients with head lice. The participants underwent eye examination and dry combing by a trained professional. The subjects were randomly divided into three groups and treated with one of the three methods of permethrin application: permethrin shampoo for 10 min, permethrin shampoo for 1 h, or permethrin cream for 10 min on a weekly basis for 3 weeks.

RESULTS:

Of the 157 participants, 154 completed the study. The group treated with permethrin shampoo for 1 h had the shortest average time for eradication of lice at 1.226 ± 0.422 weeks, which was significantly lower than the other two groups. Additionally, the 1-h permethrin shampoo group had the lowest time for scalp itching of 2.15 ± 0.632 weeks, which was significantly lower than the other two groups. Moreover, the rate of lice eradication in the first week was significantly higher in the 1-h permethrin shampoo group.

CONCLUSION:

The results of this study suggest that the use of 1% permethrin shampoo for 1 h is more effective in eradicating head lice within the first week of treatment and in relieving scalp itching during the second week.

• Authors: Nasibeh Ghalandari, Aida Edalatkhah Tatafi, Ghader Mohammadnezhad, Maryam Nasimi, Hadi Esmaily
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 22 Issue 11 Pg. 3065-3071 (Nov 2023) ISSN: 1473-2165 [Electronic] England
• PMID: 37218578 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.