Abstract |
The lysosome is an important target for realizing antitumor therapy. Lysosomal cell death exerts significant therapeutic effects on apoptosis and drug-resistance. The development of lysosome-targeting nanoparticles to obtain efficient cancer treatment is challenging. In this article, nanoparticles composed of DSPE@M- SiPc and possessing bright two-photon fluorescence, lysosome targeting ability, and photodynamic therapy multifunctionalities are prepared by encapsulating morpholinyl-substituted silicon phthalocyanine (M- SiPc) with 1,2-distearoyl-sn-glycero-3- phosphoethanolamine-N-[methoxy(poly( ethylene glycol))-2000] ( DSPE). Two photon fluorescence bioimaging showed that M- SiPc and DSPE@M- SiPc mainly locate in lysosomes after cellular internalization. Upon irradiation, DSPE@M- SiPc effectively generates reactive oxygen species and damages the function of lysosome, subsequently leading to lysosomal cell death. DSPE@M- SiPc is a promising photosensitizer for cancer treatment.
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Authors | Hongjie Yu, Jianling Chen, Xiuqin Chen, Tiantian Zhang, Yuyang Li, Kuizhi Chen, Yiru Peng, Linying Chen |
Journal | Frontiers in bioengineering and biotechnology
(Front Bioeng Biotechnol)
Vol. 11
Pg. 1181448
( 2023)
ISSN: 2296-4185 [Print] Switzerland |
PMID | 37214289
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Yu, Chen, Chen, Zhang, Li, Chen, Peng and Chen. |