Superior mesenteric artery occlusion shock in cats: modification of the endotoxemia by antilipopolysaccharide antibodies (anti-LPS).

Abstract

We measured the time course of elevated plasma LPS concentration caused by a temporary intestinal ischemia using the superior mesenteric artery (SMA) occlusion shock model in anesthetized cats. The systemic plasma LPS increased from 0.075 +/- 0.006 ng/cc to 0.219 +/- 0.026 ng/cc (P less than 0.001) during the occlusion period. On release of the clamp, the plasma LPS concentration rose rapidly to 0.716 +/- 0.122 ng/cc (P less than 0.001) within 20 min. Thereafter, it declined to reach baseline levels after 100-120 min reperfusion. A total of 21 animals received IV 1.0 cc/kg antilipopolysaccharide hyperimmune equine plasma (anti-LPS) either 1.5 hr before the occlusion or at 0, 10, or 20 min after release of the occlusion. Prophylactic anti-LPS prevented any rise in plasma LPS both during and after release of the occlusion. The administration of anti-LPS during the reperfusion period completely reversed the endotoxemia caused by intestinal ischemia within 5-10 min. This rapidity of response to anti-LPS may be important in the previously reported therapeutic benefit of anti-LPS.

• Authors: P Gathiram, S L Gaffin, M T Wells, J G Brock-Utne
• Journal: Circulatory shock (Circ Shock) Vol. 19 Issue 2 Pg. 231-7 ( 1986) ISSN: 0092-6213 [Print] United States
• PMID: 3719923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulins
• Lipopolysaccharides
• antilipopolysaccharide antibodies

Topics

• Animals
• Cats
• Female
• Immunoglobulins
• Lipopolysaccharides (blood, immunology, therapeutic use)
• Male
• Mesenteric Arteries
• Mesenteric Vascular Occlusion (blood)
• Perfusion
• Shock, Septic (therapy)