Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.

Abstract

Seborrheic Dermatitis (SD) is a chronic and relapsing inflammatory condition accompanied by erythema, flaking and itching. Dandruff is a milder form of SD. Selenium disulfide (SeS2) is beneficial in both conditions.

OBJECTIVES:

to assess the efficacy of SeS2-based shampoo in dandruff/SD.

MATERIALS & METHODS:

an international, multicenter, observational study was conducted in 1407 adult subjects. SeS2- based shampoo was used 2 to 3 times per week for 4 weeks. Clinical efficacy criteria included improvement of hair, flaking, erythema and irritation on a scale from 0 to 5; investigator satisfaction was assessed at month 3 from 0 to 10. The subjects rated the impact of their hair problem (0 to 5), efficacy and satisfaction with SeS2-based shampoo at month 3. Tolerance was assessed throughout the study.

RESULTS:

At baseline, 68.2% had a flake severity score of 3-5, 49.9% an erythema severity score of 3-5, and 46.2% an irritation severity score of 3-5; 28.2% were bothered and 41.5% were very bothered. At study end, SD/D had at least clearly improved in 89.6% of subjects. All clinical signs had significantly (p<0.001) improved. 95.6% of subjects reported less pruritus. Significantly fewer (15.4%, p<0.0001) subjects were still bothered. The overall subject satisfaction score was 8.9±1.4; 97.6% of investigators were satisfied or very satisfied. Tolerance was good or very good in 98.8% of subjects.

CONCLUSION:

A SeS2-based shampoo applied 2 to 3 times per week is efficient and well tolerated in dandruff and SD.

• Authors: Gabriela Turcu, Claudia Artenie, Danuta Nowicka, Monika Arenbergerová, Elisabet Lazaridou, Kuzma Khobzei, Arzu Ataseven, Martina Part, Stéphanie Leclerc-Mercier
• Journal: European journal of dermatology : EJD (Eur J Dermatol) Vol. 33 Issue S1 Pg. 19-23 (Mar 01 2023) ISSN: 1952-4013 [Electronic] France
• PMID: 37098775 (Publication Type: Observational Study, Multicenter Study, Journal Article)

Chemical References

• selenium disulfide
• Hair Preparations

Topics

• Adult
• Humans
• Dermatitis, Seborrheic (drug therapy)
• Dandruff
• Hair Preparations (therapeutic use)
• Erythema (drug therapy)
• Pruritus (drug therapy, etiology)
• Scalp Dermatoses (drug therapy)