Abstract | OBJECTIVE: STUDY DESIGN: Retrospective analysis. SETTING: METHODS: Patients with the 6 most common histologic subtypes of parotid cancer were selected. Primary outcomes were the distribution of positive lymph nodes by level and overall survival assessed by Cox analysis. Secondary outcomes included predictors of extended lymph node involvement (≥3 lymph nodes or Level IV/V involvement), via logistic regression. RESULTS: Six thousand nine hundred seventy-seven patients with acinic cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, carcinoma ex pleomorphic adenoma (CExPA), mucoepidermoid carcinoma, and salivary duct carcinoma (SDC) were included. Among cN0 patients, 8.2% of low-grade tumor patients had occult nodal metastasis versus 30.9% in high-grade tumor patients. Elective neck dissection was not associated with an overall survival benefit (adjusted hazard ratio: 1.10; 0.94-1.30, p = .238). Among cN+ tumors, CExPA (odds ratio [OR]: 1.88, 1.05-3.39, p = .034) and high-grade pathology (OR: 3.03, 1.87-4.93, p < .001) were predictive of having ≥3 pathologic nodes. CExPA (OR: 2.13, 1.22-3.72, p = .008), adenocarcinoma (OR: 1.60, 1.11-2.31, p = .013), SDC (OR: 1.92, 1.17-3.14, p < .01), and high-grade pathology (OR: 3.61, 2.19-5.97, p < .001) were predictive of Level IV/V neck involvement. CONCLUSIONS:
|
Authors | Rohith S Voora, Bharat Panuganti, Joseph Califano, Charles Coffey, Theresa Guo |
Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
(Otolaryngol Head Neck Surg)
Vol. 168
Issue 5
Pg. 1067-1078
(05 2023)
ISSN: 1097-6817 [Electronic] England |
PMID | 36939401
(Publication Type: Journal Article)
|
Copyright | © 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation. |
Topics |
- Humans
- Parotid Neoplasms
(surgery, pathology)
- Retrospective Studies
- Lymphatic Metastasis
(pathology)
- Neck Dissection
- Adenocarcinoma
(pathology, secondary, surgery)
- Salivary Gland Neoplasms
(pathology)
- Lymph Nodes
(pathology)
- Neoplasm Staging
|