HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway.

Abstract
Bavachin is a dihydroflavonoid compound isolated from Psoralea corylifolia, and exhibits anti-bacterial, anti-inflammatory, anti-tumor and lipid-lowering activities. Recent attention has gradually drawn on bavachin-induced apoptosis in many human cancer cell lines. However, the anti-cancer effects and related mechanisms in colorectal cancer remain unknown. Here, we investigated the effects of bavachin on colorectal cancer in vivo and in vitro. The results showed that bavachin inhibited the proliferation of human colorectal cancer cells and induce apoptosis. These changes were mediated by activating the MAPK signaling pathway, which significantly up-regulated the expression of Gadd45a. Furthermore, Gadd45a silencing obviously attenuated bavachin-mediated cell apoptosis. Inhibition of the MAPK signaling pathway by JNK/ERK/p38 inhibitors also weakened the up-regulation of Gadd45a by bavachin. The anticancer effect of bavachin was also validated using a mouse xenograft model of human colorectal cancer. In conclusion, these findings suggest that bavachin induces the apoptosis of colorectal cancer cells through activating the MAPK signaling pathway.
AuthorsMengru Wang, Baopeng Tian, Jie Shen, Shilin Xu, Cong Liu, Ling Guan, Min Guo, Jie Dou
JournalChinese journal of natural medicines (Chin J Nat Med) Vol. 21 Issue 1 Pg. 36-46 (Jan 2023) ISSN: 1875-5364 [Electronic] China
PMID36641231 (Publication Type: Journal Article)
CopyrightCopyright © 2023 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
Chemical References
  • bavachin
  • Flavonoids
  • Proteins
  • GADD45A protein, human
  • Cell Cycle Proteins
Topics
  • Humans
  • Signal Transduction
  • Flavonoids (pharmacology)
  • Proteins (metabolism, pharmacology)
  • MAP Kinase Signaling System
  • Colorectal Neoplasms (drug therapy, genetics, metabolism)
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Cycle Proteins (genetics, metabolism, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: