A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis.

Abstract

The deficient catalytic activity of nanozymes and insufficient endogenous H2 O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2 @CA) is presented that is made from few-layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H2 O2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.

• Authors: Longwei Wang, Xiaodi Zhang, Zhen You, Zhongwei Yang, Mengyu Guo, Jiawei Guo, He Liu, Xiaoyu Zhang, Zhuo Wang, Aizhu Wang, Yawei Lv, Jian Zhang, Xin Yu, Jing Liu, Chunying Chen
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 62 Issue 11 Pg. e202217448 (03 06 2023) ISSN: 1521-3773 [Electronic] Germany
• PMID: 36585377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 Wiley-VCH GmbH.

Chemical References

• molybdenum disulfide
• Molybdenum
• cinnamaldehyde
• Glutathione
• Hydrogen Peroxide

Topics

• Humans
• Ferroptosis
• Molybdenum
• Neoplasms (diagnostic imaging, drug therapy)
• Catalysis
• Glutathione
• Tumor Microenvironment
• Hydrogen Peroxide