High-dose chemotherapy and autologous stem cell transplantation in primary lymphomatoid granulomatosis of the central nervous system.

Abstract

Primary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare lymphoid neoplasia associated Epstein-Barr Virus (EBV) and often accompanied by immunodeficiencies. No treatment standards have been defined yet. However, due to often devastating neurologic sequelae and based on similarities to diffuse large B-cell lymphoma, curative treatment requires intensive therapy protocols resembling protocols applied in CNS lymphoma. Here, the clinical courses and treatments of four primary CNS-LG patients in analogy to aggressive CNS-lymphomas including methotrexate, thiotepa, cytarabine, carmustine, and rituximab are presented. This is the first report on high-dose chemotherapy with CNS-directed drugs and autologous blood stem cell transplantation in primary CNS-LG.

• Authors: Verena Nilius-Eliliwi, Hannes Treiber, Sabine Seidel, Deepak B Vangala, Roland Schroers
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 149 Issue 9 Pg. 5729-5732 (Aug 2023) ISSN: 1432-1335 [Electronic] Germany
• PMID: 36566338 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Methotrexate
• Thiotepa
• Cytarabine
• Carmustine
• Rituximab
• Antineoplastic Agents

Topics

• Lymphomatoid Granulomatosis (drug therapy, surgery)
• Methotrexate (therapeutic use)
• Thiotepa (therapeutic use)
• Cytarabine (therapeutic use)
• Carmustine (therapeutic use)
• Rituximab (therapeutic use)
• Central Nervous System Viral Diseases (drug therapy, surgery)
• Epstein-Barr Virus Infections (drug therapy, surgery)
• Humans
• Antineoplastic Agents (therapeutic use)
• Male
• Female
• Adult
• Middle Aged
• Peripheral Blood Stem Cell Transplantation
• Transplantation, Autologous
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Treatment Outcome