Comparative Study of the Efficacy of Autologous Tooth Bone Powder and Inorganic Bovine Bone Powder on the Repair of Jaw Defects.

Abstract

Context:

The main pathological features of jaw cysts are bone defects. Obtaining autologous bone for transplantation repair has been associated with postoperative complications, and the amount of bone that dentist can collect is limited. Studies have found that autologous tooth bone powder is safe and has good bone-formation ability and stability.

Objective:

The study intended to examine the efficacy of implantation of autologous tooth bone powder and inorganic bovine bone powder, after marsupialization and second-stage curettage for large jaw cysts that dentist can't directly remove by surgery in clinical practice.

Design:

The research team designed a prospective randomized controlled trial.

Setting:

The study took place in the Head and Neck Surgery Department at Chongqing University Cancer Hospital in Chongqing, China.

Participants:

Participants were 60 patients at the hospital between 2016 and 2018 who had mandibular cysts that surgical operation couldn't directly remove by surgery in clinical practice.

Intervention:

At 4 months after curettage, the research team randomly divided participants into three groups: (1) an intervention group who received implants of autologous tooth bone powder into the bone defects, (2) a positive control group who received implants of inorganic bovine bone powder, and (3) a negative control group who received no implants of any material.

Outcome Measures:

The research team performed: (1) periodontal probing at a fixed anatomical point for the intervention and both control groups postintervention at one day and 4 months after surgery and recorded the changes in probing depth and (2) computed tomography (CT) scans at baseline one day before and postintervention at 4 months after the implantation to determine changes in the bone mineral density and compared them among the three groups.

Results:

The change in the height of the intervention group's fixed anatomical point postintervention at 4 months after surgery was significantly smaller than that of the positive control group (P < .05). In the CT scan analysis, the differences between the intervention and negative control groups and between the positive and negative control groups were statistically significant (P < .05); however, the difference between the intervention and positive control groups wasn't significant (P > .05).

Conclusions:

Autologous tooth bone powder and inorganic bovine bone powder can effectively repair bone defects caused by large jaw cysts and that the repaired effect may be better than that of spontaneous osteogenesis. The autologous tooth bone powder was associated with lower levels of bone loss than those seen with use of inorganic bovine bone powder.

• Authors: Yi-Xiu Liu, Hong-Peng Wang, Jian Wu, Yu-Lian Zhang
• Journal: Alternative therapies in health and medicine (Altern Ther Health Med) Vol. 29 Issue 2 Pg. 264-270 (Mar 2023) ISSN: 1078-6791 [Print] United States
• PMID: 36399081 (Publication Type: Randomized Controlled Trial, Journal Article)

Chemical References

• Powders

Topics

• Humans
• Animals
• Cattle
• Powders
• Prospective Studies
• Jaw Cysts
• China