1,2,3-Triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens.

Abstract

ESKAPE pathogens, as priority 1 and 2 pathogens, are prevalent infectious agents associated with high morbidity and mortality. ESKAPE can cause broad-spectrum diseases with increasing tendency of resistance acquisition to antibiotics and have enhanced the urge for the development of alternate therapeutics. 1,2,3-Triazole, a highly privileged moiety for the discovery of novel drugs, not only can act as a linker to tether different pharmacophores, but also can serve as a pharmacophore. Notably, several 1,2,3-triazole-containing hybrids which are exemplified by cefatrizine, radezolid and tazobactam have already approved as antibiotics to treat infections caused by various organisms including ESKAPE pathogens and their drug-resistant forms, revealing that 1,2,3-triazole-containing hybrids are useful prototypes for clinical deployment in the control of bacterial infections. The purpose of the present review article is to provide an emphasis on the current scenario (2018-2022) of 1,2,3-triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens to facilitate further rational design of more effective candidates.

• Authors: Cui Deng, Heng Yan, Jun Wang, Kai Liu, Bao-Shan Liu, Yu-Min Shi
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 244 Pg. 114888 (Dec 15 2022) ISSN: 1768-3254 [Electronic] France
• PMID: 36334453 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Elsevier Masson SAS. All rights reserved.

Chemical References

• Triazoles
• Anti-Bacterial Agents

Topics

• Humans
• Microbial Sensitivity Tests
• Triazoles (pharmacology)
• Anti-Bacterial Agents (pharmacology)
• Bacterial Infections (drug therapy)