Surface modification of titanium with antibacterial porous N-halamine coating to prevent peri-implant infection.

Abstract

Peri-implant infection remains one of the greatest threats to orthopedics. The construction of bone implants with good antibacterial and osteogenic properties is beneficial for reducing the risk of implant-related infections and healing bone defects. In this study, N-halamine coating (namely N-Cl) was grafted onto alkali-heat treated titanium (Ti) using polydopamine to endow Ti-based orthopedic implants with strong bactericidal activity. Surface characterization revealed that the N-Cl coating has porous structure loaded with active chlorine (Cl+). The N-Cl coating also provided micro/nano-structured Ti surfaces with excellent antibacterial ability via transformation between N-H and N-Cl, and approximately 100% disinfection was achieved. Furthermore, the as-prepared N-Cl coating exhibited good biocompatibility and osteogenesis abilityin vitro. These results indicate that applying N-Cl coatings on Ti could prevent and treat peri-implant infections.

• Authors: Guobo Lan, Xiao Chu, Chaohui Li, Chi Zhang, Guiqiang Miao, Wenyong Li, Feng Peng, Xiaodong Zhao, Mei Li
• Journal: Biomedical materials (Bristol, England) (Biomed Mater) Vol. 18 Issue 1 (11 15 2022) ISSN: 1748-605X [Electronic] England
• PMID: 36317281 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 IOP Publishing Ltd.

Chemical References

• Titanium
• N-halamine
• Coated Materials, Biocompatible
• Anti-Bacterial Agents

Topics

• Titanium (chemistry)
• Porosity
• Coated Materials, Biocompatible (chemistry)
• Surface Properties
• Anti-Bacterial Agents (chemistry)
• Osteogenesis