Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer.

Abstract

This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental Dmean_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.

• Authors: Seung Won Seol, Brian H Lee, Timothy L Sita, Jay Ram Devineni, Tim J Kruser, Sean Sachdev, Michelle Gentile, Irene Helenowski, Bharat B Mittal
• Journal: Physics and imaging in radiation oncology (Phys Imaging Radiat Oncol) Vol. 24 Pg. 71-75 (Oct 2022) ISSN: 2405-6316 [Electronic] Netherlands
• PMID: 36217428 (Publication Type: Journal Article)
• Copyright: © 2022 The Author(s).