Abstract | OBJECTIVE: METHODS: All patients with WDLPS or DDLPS who received gemcitabine-based chemotherapy at our institution between September 2002 and January 2021 were included. Response was evaluated by an independent radiologist using RECIST 1.1. The Kaplan-Meier method was used to estimate distributions of survival outcomes and log-rank tests were used to compare survival outcomes between subgroups. RESULTS: Sixty-five WDLPS/DDLPS patients were included. Seven patients (10.8%) received a gemcitabine-based regimen more than once, totaling 72 treatments. The median age at the start of treatment was 66 years (range 32-80 years). Sixty-five (90.3%) regimens were gemcitabine- docetaxel, and 7 (9.7%) were gemcitabine alone. Majorities of treatments were for disease that was recurrent/metastatic (86.1%), was abdominal/retroperitoneal (83.3%), and had DDLPS components (88.9%), while 25.0% of treatments were for multifocal disease. The overall response rate was 9.7% (7/72). All responses were in patients with documented DDLPS. The median time to progression was 9.2 months (95% CI 5.3-12.3 months). The median overall survival from the start of therapy was 18.8 months (95% CI 13.1-32.4 months). CONCLUSION:
Gemcitabine- docetaxel is an efficacious second-line treatment for DDLPS. Though cross study comparisons are not advisable, response to gemcitabine- docetaxel compares favorably to current standard options trabectedin and eribulin. This combination is a valid comparator arm for future second-line trials in DDLPS.
|
Authors | Prapassorn Thirasastr, Heather Lin, Behrang Amini, Wei-Lien Wang, Jeffrey M Cloutier, Elise F Nassif, Emily Z Keung, Christina L Roland, Barry Feig, Dejka Araujo, Robert S Benjamin, Anthony P Conley, John A Livingston, Joseph Ludwig, Shreyaskumar Patel, Ravin Ratan, Vinod Ravi, Maria Alejandra Zarzour, Xiao Zhou, Neeta Somaiah |
Journal | Cancer medicine
(Cancer Med)
Vol. 12
Issue 4
Pg. 4282-4293
(02 2023)
ISSN: 2045-7634 [Electronic] United States |
PMID | 36151848
(Publication Type: Journal Article)
|
Copyright | © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
Chemical References |
- Docetaxel
- Gemcitabine
- Trabectedin
|
Topics |
- Humans
- Adult
- Middle Aged
- Aged
- Aged, 80 and over
- Docetaxel
(therapeutic use)
- Gemcitabine
- Retrospective Studies
- Trabectedin
(therapeutic use)
- Liposarcoma
(drug therapy, pathology)
|