Abstract | BACKGROUND: METHODS: The study comprised 88 patients, 60 patients and 28 controls, who were evaluated as having MHT, were admitted to the emergency department of our hospital within the first 3 hours of the trauma and met the inclusion criteria. CT was performed on all patients. Serum GFAP and UCH-L1 levels were measured within the first 3 hours of the trauma. RESULTS: The median serum GFAP level was 1.07 ng/mL in the group with pathology on CT and 0.42 ng/mL in the group with no pathology on CT. The median serum UCH-L1 level was 0.40 ng/mL in the group with pathology on CT and 0.39 ng/mL in the group with no pathology on CT. A statistically significant difference was found between the serum GFAP levels of the CT (+) group and the CT (-) group (p = 0.021). GFAP levels were compared according to the CT (+) and CT (-) groups with a cutoff value of ≥ 1.56 ng/mL for GFAP, which had 50% sensitivity and 97.5% specificity. This was statistically significant (p = 0.008). It was found that the UCH-L1 level of the control group was lower than the UCH-L1 levels of the CT (+) and CT (-) groups, and this difference was found to be statistically significant (p = 0.003 and p = 0.018, respectively). CONCLUSIONS: GFAP was found to be more specific than UCH-L1 in demonstrating the presence of intracranial pathology in patients with head trauma who were admitted to the emergency department in the first 3 hours after trauma.
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Authors | Zeynep M Polat, Murat Yucel, Halil I Cikriklar, Mustafa Altındiş, Yusuf Yurumez |
Journal | Clinical laboratory
(Clin Lab)
Vol. 68
Issue 8
(Aug 01 2022)
ISSN: 1433-6510 [Print] Germany |
PMID | 35975499
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Glial Fibrillary Acidic Protein
- Ubiquitin Thiolesterase
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Topics |
- Adult
- Biomarkers
(blood)
- Craniocerebral Trauma
(diagnosis)
- Glial Fibrillary Acidic Protein
(blood)
- Humans
- Turkey
- Ubiquitin Thiolesterase
(blood)
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