[Effect of hormonal therapy on the level of antibiodies to antigens of thymus epithelial tissue in myasthenia].

Abstract

With the aid of an indirect method of immunofluorenscence in the process of a study of 65 blood sera of patients with myasthenia, the authors, demonstrated significant prevalence of antibodies titres to myoid cells and to an epithelial thymus reticulum (especialey in patients with thymomas) in comparison with normals. These data my indicate an autoimmune character of myasthenia. A positive effect of hormonal therapy was accompanied by a distinct drop in the level of antibodies in patients with myasthenia which permits to assume a certain connection between hormonotherapy and its influence on the autoimmune processes.

• Authors: B M Gekht, M G Kuralesin, E V Gnezditskaia, D I Shagal
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 78 Issue 8 Pg. 1129-34 ( 1978) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Vliianile gormonal'noĭ terapii na uroven' antitel k antigenam épitelial'noĭ tkani timusa pri miastenii.
• PMID: 358705 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anabolic Agents
• Autoantibodies
• Decanoates
• Nandrolone
• Prednisolone

Topics

• Anabolic Agents (therapeutic use)
• Autoantibodies
• Decanoates (therapeutic use)
• Female
• Fluorescent Antibody Technique
• Humans
• Male
• Muscular Diseases (complications, drug therapy, immunology)
• Nandrolone (analogs & derivatives, therapeutic use)
• Prednisolone (therapeutic use)
• Thymectomy
• Thymoma (complications, radiotherapy)
• Thymus Gland (immunology)
• Thymus Neoplasms (complications, radiotherapy)