The thyroid
metastasis from
cervical cancer is extremely rare compared to other organs. It is sometimes difficult to distinguish primary
tumors from
metastases, as most metastatic
thyroid nodules are asymptomatic. In this case, a 54-year-old woman had undergone radical
hysterectomy due to cervical
tumor of stage IB1 mixed adenoneuroendocrine
carcinoma (MANEC) 5 years ago. After 3 years, ultrasound examination revealed a suspicious malignant nodule in the left lobe of thyroid gland at regular postoperative follow-up. This patient had no obvious clinical symptoms. The ultrasonography (US)-guided core needle biopsy (CNB) of the
thyroid nodule was performed on the patient. The immunohistochemistry analyses revealed that it was poorly differentiated small-cell neuroendocrine
carcinoma (SCNEC). Subsequently, the patient underwent left hemithyroidectomy plus isthmusectomy. The postoperative pathology and immunohistochemistry, combining with clinical history, confirmed that the
thyroid nodule was a
metastasis from cervical MANEC. Conventional
chemotherapy and regular follow-up were carried out after the operation. The patient was readmitted 1 year later for pancreatic metastatic lesions and died 1 month after surgery. Early detection of metastatic
cancer is potentially helpful, and when necessary, ultrasound-guided puncture biopsy can be utilized to further diagnose metastatic
thyroid cancer.