Treatment updates on tenosynovial giant cell tumor.

Abstract

PURPOSE OF REVIEW:

Diffuse-type tenosynovial giant cell tumor (dt-TGCT) is a benign clonal neoplastic proliferation arising from the synovium. Patients are often symptomatic, require multiple surgical procedures during their lifetime, and have reduced quality of life (QoL). Surgery is the main treatment with relapse rates ranging from 14 to 55%. The treatment strategy for patients with dt-TGCT is evolving. The purpose of this review is to describe current treatment options, and to highlight recent developments in the knowledge of the molecular pathogenesis of dt-TGCT as well as related therapeutic implications.

RECENT FINDINGS:

TGCT cells overexpress colony-stimulating factor 1 (CSF1), resulting in recruitment of CSF1 receptor (CSF1R)-bearing macrophages that are polyclonal and make up the bulk of the tumor, has led to clinical trials with CSF1R inhibitors. These inhibitors include small molecules such as pexidatinib, imatinib, nilotinib, DCC-3014 (vimseltinib), and the monoclonal antibody RG7155 (emactuzumab).

SUMMARY:

In conclusion, D-TGCT impairs patients' QoL. The evidence that the pathogenetic loop of D-TGCT can be inhibited has changed the therapeutic armamentarium for this condition. Clinical trials of agents that target CSF1R are currently ongoing. All this new evidence should be taken into consideration within multidisciplinary management.

• Authors: Emanuela Palmerini, Eric L Staals
• Journal: Current opinion in oncology (Curr Opin Oncol) Vol. 34 Issue 4 Pg. 322-327 (07 01 2022) ISSN: 1531-703X [Electronic] United States
• PMID: 35837703 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Protein Kinase Inhibitors

Topics

• Giant Cell Tumor of Tendon Sheath (drug therapy, pathology, surgery)
• Humans
• Neoplasm Recurrence, Local
• Protein Kinase Inhibitors (therapeutic use)
• Quality of Life
• Synovitis, Pigmented Villonodular (drug therapy, surgery)