Abstract |
Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, their clinical application is still hampered by their poor biodegradability. Herein, a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT) is reported. The PSP can further co-assemble with an amphiphilic polyester with pendant doxorubicin (DOX) in its side chains via reactive oxygen species (ROS)-responsive thioketal linkages (PEDOX ), which are denoted as NP@PEDOX /PSP. The NP@PEDOX /PSP can accumulate at tumor sites and generate ROS for photodynamic immunotherapy as well as near-infrared-II fluorescence (NIR-II) for bioimaging upon irradition at 808 nm. The ROS could break up thioketal linkages in PEDOX , resulting in rapid doxorubicin (DOX) release for PACT. Finally, both PEDOX and PSP are degraded sacrificially by intracellular glutathione (GSH), resulting in the dissociation of NP@PEDOX /PSP. This work highlights the application of self-sacrificially degradable PSP for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and PACT in cancer therapy.
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Authors | Dongsheng Tang, Yingjie Yu, Jinbo Zhang, Xiying Dong, Chaoyong Liu, Haihua Xiao |
Journal | Advanced materials (Deerfield Beach, Fla.)
(Adv Mater)
Vol. 34
Issue 34
Pg. e2203820
(Aug 2022)
ISSN: 1521-4095 [Electronic] Germany |
PMID | 35817731
(Publication Type: Journal Article)
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Copyright | © 2022 Wiley-VCH GmbH. |
Chemical References |
- Polymers
- Reactive Oxygen Species
- Doxorubicin
- Glutathione
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Topics |
- Cell Line, Tumor
- Doxorubicin
(chemistry)
- Fluorescence
- Glutathione
(chemistry)
- Humans
- Immunotherapy
- Nanoparticles
(chemistry)
- Neoplasms
(diagnostic imaging, drug therapy)
- Photochemotherapy
(methods)
- Polymers
(chemistry)
- Reactive Oxygen Species
(metabolism)
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