[Toward precision surgery for Head and Neck tumors].

Abstract

Surgical resection is the most frequent curative treatment proposed to patients with head and neck cancers. It is currently integrated into specific therapeutic schemes and therapeutic stratification, but the surgical procedure itself as well as its evaluation do not rely on tumor biology. Here, we present a number of recent studies, mostly based on system analyses and genomics, that show how tumor analyses could help to: i) define the indications and the extent of surgical resections; ii) personalize the perioperative management; iii) facilitate the detection of post-surgical tumor recurrence. Overall, these studies provide a proof of principle that precision surgery, i.e. based on tumor biology, similarly to precision medicine, is applicable to head and neck cancers.

• Authors: Zuzana Saidak, Antoine Galmiche, Martial Ouendo, Denis Chatelain, Jean-Marc Constans, Sylvie Testelin
• Journal: Medecine sciences : M/S (Med Sci (Paris)) 2022 Jun-Jul Vol. 38 Issue 6-7 Pg. 562-569 ISSN: 1958-5381 [Electronic] France
• Vernacular Title: Principe et applicabilité de la chirurgie de précision aux cancers de la tête et du cou.
• PMID: 35766854 (Publication Type: Journal Article)
• Copyright: © 2022 médecine/sciences – Inserm.

Topics

• Head and Neck Neoplasms (diagnosis, surgery)
• Humans
• Neoplasm Recurrence, Local
• Precision Medicine