Cu2+ Embedded Three-Dimensional Covalent Organic Framework for Multiple ROS-Based Cancer Immunotherapy.

Abstract

Reactive oxygen species (ROS)-based cancer treatments have attracted much attention in recent years. However, most patients respond poorly to the monotypic ROS during these treatments. In this work, a multiple ROS-based cancer immunotherapy synergistic strategy has been developed to enhance the therapeutic effect of cancer. We prepare a three-dimensional covalent organic framework (3D COF-TATB), and embed copper ions (Cu2+) into the skeleton to obtain multifunctional nanomaterial, 3D Cu@COF-TATB. In this system, porphyrins in 3D COF-TATB serve not only as the photosensitizer for photodynamic process to produce singlet oxygen(1O2), but also as the binding sites to complex with Cu2+. Cu2+ can be reduced by the GSH to generate Cu+ to produce hydroxyl radical (•OH) through the Fenton-like reaction. Moreover, the generated multiple types of ROS induce the immunogenic cell death (ICD) of cancer cells to improve the immunogenicity and further activate an immune response for attacking the tumor. Combining with the immunoblocking inhibitor (aPD-1), 3D Cu@COF-TATB can effectively inhibit the tumor growth. This work will provide a guidance for multimodal cancer therapy in future clinical treatment settings.

• Authors: Xia Zhang, Shenglin Wang, Kun Tang, Wei Pan, Huanjun Xu, Yanhua Li, Yanan Gao, Na Li, Bo Tang
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 14 Issue 27 Pg. 30618-30625 (Jul 13 2022) ISSN: 1944-8252 [Electronic] United States
• PMID: 35763788 (Publication Type: Journal Article)

Chemical References

• Metal-Organic Frameworks
• Photosensitizing Agents
• Reactive Oxygen Species
• Copper

Topics

• Cell Line, Tumor
• Copper (chemistry)
• Humans
• Immunotherapy
• Metal-Organic Frameworks (chemistry)
• Neoplasms (drug therapy)
• Photosensitizing Agents (chemistry)
• Reactive Oxygen Species (metabolism)