Abstract | PURPOSE: MATERIALS AND METHODS: A retrospective study was performed in aCSC patients treated with one-third dose PDT and followed up for 36 months. Demographic information and clinical features were compared. A logistic regression model was used to evaluate the associated factor of aCSC recurrence. RESULTS: There were 162 patients with aCSC included in current study. 36-month after one-third dose PDT, good recovery was identified in 131 patients (80.86%), whereas 31 cases (19.14%) developed recurrence. Significant between-group differences were observed in baseline age, the right, left and both eyes, best-corrected visual acuity (BCVA), presenting with pigment epithelium detachment (PED), retinal pigment epithelium (RPE) damage and subfoveal choroidal thickness (SCT) level (P = 0.005, P < 0.001, P < 0.001, P < 0.001, P = 0.006, and P < 0.001, respectively). The recurrence of aCSC was associated with presenting with PED (odds ratio = 1.78; 95% CI, 1.45-1.98; P < 0.001), RPE damage (OR = 1.13; 95%CI: 1.08-1.23; P < 0.001), baseline BCVA (OR = 0.96; 95%CI: 0.95 - 0.99; P = 0.001), and SCT level (OR = 1.18; 95%CI: 1.02-1.20; P < 0.001). CONCLUSION: In acute CSC after treatment of one-third dose PDT, recurrence is associated with RPE damage, baseline BCVA and SCT level. Our findings will assist clinicians to evaluate aCSC in clinical practice and provide insights into the prevention of recurrence.
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Authors | Xinyue Zhang, Xiaotong Zhuang, Jie Dong, Bo Fu, Li Xu |
Journal | Photodiagnosis and photodynamic therapy
(Photodiagnosis Photodyn Ther)
Vol. 39
Pg. 102984
(Sep 2022)
ISSN: 1873-1597 [Electronic] Netherlands |
PMID | 35753673
(Publication Type: Journal Article)
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Copyright | Copyright © 2022. Published by Elsevier B.V. |
Chemical References |
- Photosensitizing Agents
- Porphyrins
- Verteporfin
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Topics |
- Acute Disease
- Central Serous Chorioretinopathy
(drug therapy)
- Fluorescein Angiography
- Humans
- Photochemotherapy
(methods)
- Photosensitizing Agents
(therapeutic use)
- Porphyrins
(therapeutic use)
- Retinal Detachment
(complications)
- Retrospective Studies
- Tomography, Optical Coherence
- Treatment Outcome
- Verteporfin
(therapeutic use)
- Visual Acuity
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