Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review.

Abstract

BACKGROUND:

Primary clear cell adenocarcinoma of the urethra is extremely rare, reported only in single case reports, and its histological origin is not clear. There is no standard treatment for CCAU at present, and surgery is still the main treatment for CCAU without distant metastasis.

CASE PRESENTATION:

A 67-year-old female complained of gross hematuria with frequent micturition and urgency. No urethral diverticulum was found by cystoscopy or MRI, and the mass grew around the urethra. Urethral and anterior pelvic viscera resection was performed. Clear cell adenocarcinoma was confirmed by immunohistochemistry after the operation, and no recurrence or metastasis was found after one year of follow-up.

CONCLUSION:

CCAU is very rare, and most cases originate from the urethral diverticulum and some may also originate from tissues around the urethra. For CCAU patients without distant metastasis, the main treatment is still surgery, and radiotherapy and chemotherapy can be performed for patients with distant metastasis. Gene detection may provide guidance for the precise chemotherapy of CCAU.

• Authors: Jianguang Miao, Jiebin Hu, Jilin Wu, Wei Guo, Jinbo Chen, Jin Li
• Journal: BMC women's health (BMC Womens Health) Vol. 22 Issue 1 Pg. 251 (06 24 2022) ISSN: 1472-6874 [Electronic] England
• PMID: 35751118 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: © 2022. The Author(s).

Topics

• Adenocarcinoma, Clear Cell (diagnosis, pathology, therapy)
• Aged
• Diverticulum (surgery)
• Female
• Humans
• Magnetic Resonance Imaging
• Urethral Neoplasms (diagnosis, pathology, therapy)
• Urinary Tract (pathology)