Anemia and fibroblast growth factor 23 elevation in chronic kidney disease: homeostatic interactions and emerging therapeutics.

Abstract

PURPOSE OF REVIEW:

Chronic kidney disease (CKD) is a progressive disorder that is associated with development of elevated fibroblast growth factor 23 (FGF23) levels and anemia. Here, we review recent literature that extends our current knowledge on the interactions between FGF23 and anemia in CKD and the impact of anemia-targeting therapeutics on FGF23 elevation in CKD.

RECENT FINDINGS:

The anemia of CKD is primarily driven by a lack of erythropoietin (EPO) and iron deficiency. In addition to EPO and iron replacement, novel drug classes to treat anemia have been approved or are in clinical development. A recent observational study provides supportive evidence for the hypothesis that FGF23 elevation in CKD mediates adverse effects of iron deficiency on the cardiovascular system in patients with CKD. Preclinical and clinical studies revealed that ferric citrate (FC), and hypoxia-induced factor-prolyl hydroxylase inhibitor (HIF-PHI) treatment may reduce elevated FGF23 levels in CKD, suggesting that correcting anemia in CKD could potentially lower FGF23 levels. However, as we describe, HIF-PHI have context-dependent effects. Moreover, whether a reduction in FGF23 will improve patient outcomes in patients with CKD remains to be determined.

SUMMARY:

With the emergence of novel therapeutics to treat oxygen and iron utilization deficits in CKD, studies have investigated the impact of these new drugs on FGF23. Several of these drugs, including FC and HIF-PHIs, alleviate iron homeostasis alterations in CKD and are associated with FGF23 reduction. Herein, we review the relationships between oxygen/iron sensing and FGF23 in CKD, recent findings which link FGF23 with cardiac dysfunction, as well as future translational and clinical avenues.

• Authors: Rafiou Agoro, Kenneth E White
• Journal: Current opinion in nephrology and hypertension (Curr Opin Nephrol Hypertens) Vol. 31 Issue 4 Pg. 320-325 (07 01 2022) ISSN: 1473-6543 [Electronic] England
• PMID: 35703246 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Fibroblast Growth Factors
• Fibroblast Growth Factor-23
• Iron
• Oxygen

Topics

• Anemia (drug therapy, etiology)
• Fibroblast Growth Factor-23
• Fibroblast Growth Factors (metabolism)
• Homeostasis
• Humans
• Iron (therapeutic use)
• Oxygen
• Renal Insufficiency, Chronic (complications, drug therapy, metabolism)