Abstract | BACKGROUND: METHODS: In the present retrospective study, we reviewed the medical records of patients with advanced NSCLC who received cancer immunotherapy as first-line systemic therapy. Clinical immune predictive scores were defined according to multivariate analysis of progression-free survival (PFS) and overall survival (OS). RESULTS: A total of 157 patients were included in the present study (75 treated with PD-1/PD-L1 inhibitors + chemotherapy; 82, pembrolizumab monotherapy). Multivariate analysis for PFS revealed that PD-L1 tumor proportion scores <50%, a total target lesion diameter ≥76 mm, and cancer cachexia were independently associated with poor PFS. Multivariate analysis for OS revealed that ≥4 metastases and cancer cachexia were significantly associated with poor OS. In the immune predictive model, the median PFS was 21.7 months in the low-risk group (N = 41); 7.6 in the medium-risk group (N = 64); and 3.0 in the high-risk group (N = 47). The median OS were not reached, 22.4 and 9.1 months respectively. Our immune predictive model was significantly associated with PFS (p < 0.001) and OS (p < 0.001). CONCLUSION: We proposed the immune predictive model, including tumor burden and cancer cachexia, which may predict the efficacy and survival outcome of first-line immunotherapy in advanced NSCLC.
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Authors | Taichi Miyawaki, Tateaki Naito, Kosei Doshita, Hiroaki Kodama, Mikiko Mori, Naoya Nishioka, Yuko Iida, Eriko Miyawaki, Nobuaki Mamesaya, Haruki Kobayashi, Shota Omori, Ryo Ko, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Keita Mori, Hideyuki Harada, Masahiro Endo, Kazuhisa Takahashi, Toshiaki Takahashi |
Journal | Thoracic cancer
(Thorac Cancer)
Vol. 13
Issue 14
Pg. 2064-2074
(07 2022)
ISSN: 1759-7714 [Electronic] Singapore |
PMID | 35698259
(Publication Type: Journal Article, Review)
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Copyright | © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Antineoplastic Agents, Immunological
- B7-H1 Antigen
- Programmed Cell Death 1 Receptor
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Topics |
- Antineoplastic Agents, Immunological
(therapeutic use)
- B7-H1 Antigen
(therapeutic use)
- Cachexia
(etiology, therapy)
- Carcinoma, Non-Small-Cell Lung
(complications, drug therapy)
- Humans
- Immunotherapy
- Lung Neoplasms
(complications, drug therapy)
- Programmed Cell Death 1 Receptor
(therapeutic use)
- Retrospective Studies
- Tumor Burden
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