Abstract | BACKGROUND: METHODS: A systematic review of articles was conducted according to PRISMA and AMSTAR-2 guidelines. 11 studies were included in the analysis. RESULTS: We included in our analysis 212 patients subdivided in three groups: 64 in the HIPEC group (57 with prophylactic intent and 7 with curative intent), 55 in the PIPAC group and 93 in the NIPEC group. Primary outcomes were represented by survival rates; we evidenced at an observation time of three years a survival of 24% in the HIPEC group (25.5% in the prophylactic arm and 6.2% in the curative arm), 5.3% in the PIPAC group and 7.9% in the NIPEC group. CONCLUSIONS:
HIPEC could be considered as a promising technique for prophylaxis and treatment of peritoneal metastasis (PM) in case of borderline resectable and locally advanced disease. Increased survival rates emerged without additional morbidity when surgical resection and CRS are possible. In addition, our data about PIPAC and NIPEC as palliative treatment in unresectable disease seems to identify more favorable survival rates compared to literature.
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Authors | Simone Frassini, Francesca Calabretto, Stefano Granieri, Paola Fugazzola, Jacopo Viganò, Nicola Fazzini, Luca Ansaloni, Lorenzo Cobianchi |
Journal | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
(Eur J Surg Oncol)
Vol. 48
Issue 9
Pg. 1911-1921
(09 2022)
ISSN: 1532-2157 [Electronic] England |
PMID | 35688711
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright © 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved. |
Chemical References |
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Topics |
- Adenocarcinoma
(drug therapy)
- Aerosols
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Combined Modality Therapy
- Cytoreduction Surgical Procedures
(methods)
- Humans
- Hyperthermia, Induced
(methods)
- Pancreatic Neoplasms
(drug therapy)
- Peritoneal Neoplasms
(drug therapy, secondary)
- Pancreatic Neoplasms
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