Biodegradable electrospun nanofibrous platform integrating antiplatelet therapy-chemotherapy for preventing postoperative tumor recurrence and metastasis.

Abstract

The perioperative trauma-related platelet recruitment and activation severely affect tumor recurrence and metastasis. Therefore, efficiently killing residual tumor cells and simultaneously inhibiting platelet activation to block platelet-cancer cell interaction might be a promising strategy to prevent postoperative tumor recurrence and metastasis. Methods: Biodegradable PLGA electrospun nanofibrous films co-delivering doxorubicin-loaded tumor repopulating cell-derived microparticles (DOX-MPs) and aspirin (ASA) were developed as the implant materials (DOX-MPs/ASA@NF) for postoperative in-situ treatment. The characterization, cytotoxicity against tumor cells, inhibition in platelet activation-triggered proliferation, migration and metastasis of tumor cells and in vivo anti-recurrence and anti-metastasis activity induced by DOX-MPs/ASA@NF were systematically evaluated. Results: PLGA nanofibrous films facilitate the enhanced distribution of DOX-MPs as well as DOX-MPs and ASA release in a time-programmed manner within the tumor resection cavity. The released DOX-MPs efficiently kill the residual tumor cells, while ASA decreases platelet activation and inhibits platelet-promoted proliferation, migration and metastasis of tumor cells, resulting in the remarkable inhibition of postoperative tumor recurrence and metastasis. Conclusions: DOX-MPs/ASA@NF may be a promising candidate to prevent the recurrence and metastasis of resectable tumors.

• Authors: Jianye Li, Jiaojiao Li, Yuzhu Yao, Tuying Yong, Nana Bie, Zhaohan Wei, Xin Li, Shiyu Li, Jiaqi Qin, Haibo Jia, Qing Du, Xiangliang Yang, Lu Gan
• Journal: Theranostics (Theranostics) Vol. 12 Issue 7 Pg. 3503-3517 ( 2022) ISSN: 1838-7640 [Electronic] Australia
• PMID: 35547751 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The author(s).

Chemical References

• Platelet Aggregation Inhibitors
• Doxorubicin

Topics

• Cell Line, Tumor
• Doxorubicin (pharmacology)
• Humans
• Nanofibers
• Neoplasm Recurrence, Local (drug therapy, prevention & control)
• Neoplasm, Residual (drug therapy)
• Platelet Aggregation Inhibitors