Abstract |
Vitiligo is an acquired depigmenting disorder in which destruction of skin melanocytes. In recent years, 308-nm excimer laser (308-nm EL) and topical tacrolimus have been extensively used to treat vitiligo. This study aimed to investigate the effectiveness and safety of combined treatment of 308-nm EL and topical tacrolimus for treating periocular vitiligo compared to 308-nm EL monotherapy. This study is a retrospective observational study, involving 58 Chinese patients of periocular vitiligo, divided into two groups: the control group (28 patients) treated with 308-nm EL; and the experimental group (30 patients) treated with 308-nm EL and topical tacrolimus 0.1% ointment. Repigmentation was assessed at four grades. In the control group, there were four patients (14%) with poor repigmentation, eleven patients (39%) with moderate repigmentation, ten patients (36%) with good repigmentation, three patients (11%) with excellent repigmentation. In the experimental group, two patients (7%) experienced poor repigmentation, six patients (20%) experienced moderate repigmentation, fifteen patients (50%) experienced good repigmentation, seven patients (23%) experienced excellent repigmentation. The experimental group efficacy rate (good and excellent repigmentation) was 73.3%, higher than 46.4% for the control group (p = 0.037). Our findings suggest that both treatments are safe and the combination of tacrolimus and 308-nm EL is more effective than 308-nm EL alone for periocular vitiligo.
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Authors | Fangyan Zhou, Shisheng Chen, Wanwan Jin, Yuwen Lu, Yu Gao, Jianming Wu |
Journal | Dermatologic therapy
(Dermatol Ther)
Vol. 35
Issue 7
Pg. e15556
(07 2022)
ISSN: 1529-8019 [Electronic] United States |
PMID | 35514034
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2022 Wiley Periodicals LLC. |
Chemical References |
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Topics |
- Combined Modality Therapy
- Humans
- Lasers, Excimer
(adverse effects)
- Retrospective Studies
- Tacrolimus
(adverse effects)
- Treatment Outcome
- Vitiligo
(diagnosis, therapy)
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