Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents.

Abstract

Toxoplasma gondii (T. gondii) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids 3a-c were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol 1 and sulfa drug azides 2a-c. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (3c) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs.

• Authors: Faizah S Aljohani, Nadjet Rezki, Mohamed R Aouad, Bassma H Elwakil, Mohamed Hagar, Eman Sheta, Nermine Mogahed Fawzy Hussein Mogahed, Sanaa K Bardaweel, Nancy Abd-Elkader Hagras
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 8 (Apr 11 2022) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 35457059 (Publication Type: Journal Article)

Chemical References

• Antiparasitic Agents
• Sulfonamides
• Triazoles

Topics

• Animals
• Antiparasitic Agents (pharmacology)
• Mice
• Sulfonamides (pharmacology)
• Toxoplasma
• Toxoplasmosis
• Triazoles (chemistry)