Abstract | BACKGROUND AND AIMS: METHODS AND RESULTS: Based on the Third China National Stroke Registry (CNSR-III) data from August 2015 to March 2018, we evaluated the nutritional status of patients with AIS using the TCBI. Patients were categorized according to quartile levels of the TCBI. The main outcomes were poor functional outcomes and recurrent stroke at 1-year and secondary outcomes were adverse outcomes at 3 and 6 months after stroke onset. Poor functional outcomes consisted of all-cause mortality and major disabilities. Multivariate analyses with logistic or Cox regression analysis and restricted cubic splines determined the association between the TCBI and adverse outcomes. We included 9708 patients. At the 1-year follow-up, 1323 patients (13.6%) had died or experienced major disability. The adjusted odds ratios/hazard ratios and 95% confidence intervals of the lowest quartile at 1-year were 1.47 (1.22-1.78) for poor functional outcomes, 1.46 (1.18-1.81) for major disability, and 1.34 (0.94-1.86) for all-cause mortality. Kaplan-Meier analysis demonstrated an inverse relationship between all-cause mortality and the TCBI (log-rank p < 0.05). An approximately L-shaped relationship between TCBI levels and poor functional outcomes and major disability was observed at 1-year. CONCLUSION: The novel TCBI was associated with short- and long-term adverse outcomes in AIS. Thus, it may be useful for predicting adverse outcomes in patients with AIS.
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Authors | Guitao Zhang, Yuesong Pan, Runhua Zhang, Mengxing Wang, Xia Meng, Zixiao Li, Hao Li, Yilong Wang, Xingquan Zhao, Yongjun Wang, Gaifen Liu |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 32
Issue 6
Pg. 1477-1484
(06 2022)
ISSN: 1590-3729 [Electronic] Netherlands |
PMID | 35351344
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Triglycerides
- Cholesterol
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Topics |
- Body Weight
- Brain Ischemia
(diagnosis, epidemiology, therapy)
- China
(epidemiology)
- Cholesterol
- Humans
- Ischemic Stroke
(diagnosis, epidemiology, therapy)
- Nutrition Assessment
- Prognosis
- Registries
- Stroke
(diagnosis, epidemiology, therapy)
- Triglycerides
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